What Are Exosomes? An Experts guide

What Are Exosomes? An Experts guide

An Experts guide to Exosome treatment in Esher, Surrey

As the field of aesthetics continually evolves, innovative treatments continue to emerge, offering exciting new options for skin and hair rejuvenation. Unfortunately due to a combination of factors such as lax regulation and unethical marketing practices, many treatments which can gain hype and traction in this industry sometimes have little evidence to show effectiveness and can leave patients disappointed with results as well as out of pocket.

One of the latest advancements making waves in the aesthetic world is exosome therapy. Known for their potential regenerative properties, exosomes offer promising results for those seeking improved skin texture, reduced signs of aging, and hair restoration. But what exactly are exosomes, and how do they work? Are exosomes worth the hype or do they fall on the long list of treatments which simply do not delivery the results they promise.

What Are Exosomes?

Exosomes are tiny, naturally occurring extracellular vesicles (or particles) that play a significant role in cell communication. They are nano-sized, and carry essential biochemical signals between cells. Exosomes transport various bioactive molecules, such as proteins, lipids, RNA, and DNA, which influence cell behavior and function.

In aesthetic medicine, exosomes are recently being harnessed for their potential regenerative and healing properties. They are often derived from stem cells, as these cells are rich in growth factors and signalling molecules. Exosome therapy is now gaining popularity in skin rejuvenation and hair restoration treatments due to its proposed ability to stimulate cellular repair, collagen production, and hair follicle regeneration.

How Are Exosomes Used in Aesthetic Medicine?

Exosomes are utilized in two main areas of aesthetics: skin rejuvenation and hair restoration alongside other treatments such as PRP and Polynucleotides. Here’s a closer look at the proposed mechanisms by which exosomes bring about their effects.

  1. Skin Rejuvenation

Exosome therapy is used to address a variety of skin concerns, including fine lines, wrinkles, hyperpigmentation, and uneven texture. This treatment promotes cellular repair through cell signalling, improving skin texture and tone while reducing signs of aging.

Typically, exosomes are applied through micro-needling, which allows for better penetration and absorption of exosomes into the skin. During a microneedling session, tiny, controlled punctures are made on the skin’s surface, creating microchannels that facilitate exosome delivery to the deeper layers of the skin. This combination treatment stimulates collagen production and delivers the exosomes directly where they are most effective, resulting in more radiant, youthful skin.

  1. Hair Restoration
    Exosome therapy is also gaining attention as a treatment for hair loss, particularly androgenic alopecia (pattern hair loss). Exosomes stimulate dormant hair follicles and improve scalp health, encouraging new hair growth and slowing further hair loss. They contain growth factors that can activate hair follicles, leading to thicker and healthier hair. When injected into the scalp, exosomes help reduce inflammation and support the natural growth cycle of hair follicles.

In many cases, exosome therapy is used alongside other hair restoration treatments, such as PRP (Platelet-Rich Plasma), to enhance results. The treatment process involves administering exosomes into the scalp, typically through injections, to maximize their effectiveness in targeting hair follicles.

How Do Exosomes Work?

Exosomes function as cellular messengers, carrying vital molecules between cells to coordinate tissue repair and regeneration. The specific proteins, RNA, and other molecules carried by exosomes are what make them effective in regenerative treatments. Here’s how they work:

  1. Delivery of Growth Factors
    Exosomes are packed with a variety of growth factors, which are essential for stimulating collagen production in the skin and the hair growth cycle in hair follicles. These growth factors act as signaling agents, directing cells to produce collagen, elastin, and other structural proteins that support skin firmness and hair follicle health.
  2. Anti-Inflammatory Properties
    Exosomes have anti-inflammatory effects, helping reduce inflammation in targeted areas. This is particularly beneficial for treating hair loss, as scalp inflammation can inhibit hair growth. By reducing inflammation, exosomes create a healthier environment for hair follicles to grow.
  3. Cellular Repair
    Exosomes deliver signals that encourage cellular repair and regeneration. In skin treatments, they aid in repairing damage from UV exposure, pollution, and aging. In hair treatments, they help repair damaged follicles, promoting stronger, healthier hair.
  4. Stimulation of New Cell Growth
    Exosomes help in creating new cells by activating the skin’s stem cells. This increases skin cell turnover, which improves overall skin health, brightness, and texture.

Where Are Exosomes Derived From?

Exosomes used in aesthetic treatments are generally derived from mesenchymal stem cells. These stem cells are typically sourced from human placental or adipose (fat) tissue, which is rich in growth factors and has a high regenerative potential.

It’s important to note that exosomes are purified and carefully prepared before use to ensure safety. The exosome isolation process aims to remove any cellular debris, DNA fragments, and contaminants, leaving only the purified exosomes and their beneficial signaling molecules. Reputable suppliers of exosomes for medical and aesthetic use in the UK should follow strict protocols and regulations to ensure quality and safety.

Legal Use of Exosomes in the UK

It is of upmost importance for people to be aware Human-derived exosomes are NOT approved for cosmetic use in the UK and should not be used in aesthetic practice. This is due to the risk of DNA transmission from the donor to the patient, which could cause issues if the donor had a disease or DNA issues. 

The Exosomes currently being used in the UK are typically animal or plant derived, both of these options have limited evidence to show their efficacy in humans thus far.

Are Exosomes Safe?

Safety is a top concern when considering any cosmetic treatment, and exosome therapy is no exception.

  1. Potential Side Effects: Common side effects are generally mild and temporary, including redness, swelling, and tenderness at the injection site. These typically subside within a few days.
  2. Risk of Allergic Reaction: Exosomes are bioidentical and do not contain foreign or synthetic substances, making allergic reactions rare. However, there’s always a possibility of sensitivity or mild inflammation, particularly if the individual has sensitive skin.
  3. Proper Sourcing and Preparation: Exosome safety is heavily dependent on sourcing from reputable suppliers and following proper protocols for preparation. Misuse or subpar exosome products can increase the risk of complications, underscoring the importance of choosing a qualified aesthetic doctor.
  4. Consult a Ethical Doctor: Choosing an experienced practitioner is essential to ensure that the exosomes being used are of the highest standard and actually have some evidence to suggest they can help whatever issue they are treating.

Final Thoughts: Should You Consider Exosome Therapy?

Exosome therapy represents a cutting-edge approach to aesthetics, offering a new way to address signs of aging, improve skin health, and restore hair for those in Esher, Surrey.

The science behind Exosomes is both exciting and impressive, however as stated already the evidence for use of exosomes in Aesthetics is derived largely from Human derived exosomes, not plant or animal derived. Hence its difficult to say with certainty to a patient in the UK that the current exosomes on the market (there are many) actually work and most importantly are safe.

For this reason I would recommend sticking with other more proven treatment modalities for the time being such as PRP or Polynucleotides until we know more about these messenger molecules and which brands in particular have the best safety profile and effectiveness.

Do you have any questions?

Please give us a call on 01372613080 or click on the link below to make an enquiry or book a consultation appointment at our Esher clinic.

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We look forward to hearing from you

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